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Gene name:
ANG(RNASE5);
Protein name:
Angiogenin;
Alternative:
Ribonuclease 5(RNase 5);
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur.
Function:
May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Subcellular Location:
Secreted
Protein Attributes:
Sequence length:
147
Sequence:
50:
MVMGLGVLLL | VFVLGLGLTP | PTLAQDNSRY | THFLTQHYDA | KPQGRDDRYC |
100:
ESIMRRRGLT | SPCKDINTFI | HGNKRSIKAI | CENKNGNPHR | ENLRISKSSF |
147:
QVTTCKLHGG | SPWPPCQYRA | TAGFRNVVVA | CENGLPVHLD | QSIFRRP
3D Structure:
Predicted Eptitope:
N/A
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